Genetic and Molecular Epidemiology of Multiple Myeloma Ebook

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Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 14 of all cancers and approximately 10 of hematologic malignancies The clinical manifestations of multiple myeloma include lytic bone lesions cytopenia hypercalcemia renal dysfunction hyperviscosity of the blood immunodeficiency and peripheral neuropathy Based on the clinical and genetic data probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this diseaseGenetic and Molecular Epidemiology of Multiple Myeloma EbookBy Suzanne Lentzsch Publisher Springer Print ISBN 9781461446590 1461446597 eText ISBN 9781461446606 1461446600 Copyright year 2013 Format EPUB Available from 14900 USD SKU 9781461446606

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9781461446590

Multiple myeloma is a plasma cell malignancy characterized by complex heterogenous cytogenetic abnormalities that accounts for 14 of all cancers and approximately 10 of hematologic malignancies The clinical manifestations of multiple myeloma include lytic bone lesions cytopenia hypercalcemia renal dysfunction hyperviscosity of the blood immunodeficiency and peripheral neuropathy Based on the clinical and genetic data probably all cases of multiple myeloma arise from an asymptomatic monoclonal gammopathy of unknown significance The exact mechanism of the transition from MGUS to overt multiple myeloma is still not well understood Recent oncogenomic studies have further advanced our understanding of the molecular pathogenesis of multiple myeloma This book will give a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this diseaseGenetic and Molecular Epidemiology of Multiple Myeloma EbookBy Suzanne Lentzsch Publisher Springer Print ISBN 9781461446590 1461446597 eText ISBN 9781461446606 1461446600 Copyright year 2013 Format EPUB Available from 14900 USD SKU 9781461446606